The kinome refers to hundreds of kinase enzymes that play critical roles in signaling cascades and lead to activation or inhibition of their target proteins, however the roles of many of these kinases remain poorly characterized. The Kemp lab focuses on uncovering these vulnerabilities, or this submerged portion of the iceberg, with an emphasis on investigating “the dark kinome”. There is an emphasis put on finding therapeutic treatments that target cancer-driving mutations, but in reality, “cancer cells have lots of vulnerabilities beyond what people typically look for,” adds Dr. Christopher Kemp, Professor in the Fred Hutch Human Biology and Public Health Sciences Divisions. When it comes to finding therapeutic cancer targets, “mutated cancer genes are just the tip of the iceberg, but functional genomics can help uncover the much larger, submerged portion of the iceberg,” explains Dr. Viruses, Vaccines and Infectious Diseases.Institutional Partners & Collaborations.Vaccine and Infectious Disease Division.Subscribe to Oncology Insights Newsletter.
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